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Patofisiologi Kejang Dan Perubahan Susunan Saraf Pusat Pada Eklampsia (Pathophysiology of Convulsion And Central Nervous System Changes In Eclampsia)
Eclampsia is a serious complication of pregnancy due to some neurologic complications, including convulsion and central nervous system changes in eclampsia remains unknown and continues to be the subject of extensive investigation.
Some of etiologic mechanisms that are implicated in the pathophysiology/pathogenesis of eclamptic convulsion and other central nervous system changes have included vasospasm hypertensive encphalopathy, cerebral edema (mostly vasogenic edema), the uteroplacental ischemia, and endothelial damage/endothel dysfunction. Neurologic complication of eclampsia are thought to be similar to hypertensive encephalopathy in which an acute, excessive elevation in blood pressure causes blood-brain barrier disruption, loss of cerebral blood flow autoregulation, hyperperfusion, and edema formation. Brain edema in patients with preeclarnpsia-eclampsia also was associated with abnormalities in endhotelial damage markers.
Keywords: eclampsia, convulsion, neurologic complication, hypertensive encephalopathy, cerebral edema, endothelial damage, the uteroplacental ischemia.
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