Perbandingan Aktivitas Antibakteri 4-Metilpiperazin-N-Karbonil Ampisilin dengan Ampisilin Terhadap Micrococcus luteus dart Escherichia coil (Comparative Antibacterial Activity of 4-Methylpiperazin-N-Carbonyl Ampicillin and Arnpicillin against Micrococcus luteus and Escherichia coli) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Perbandingan Aktivitas Antibakteri 4-Metilpiperazin-N-Karbonil Ampisilin dengan Ampisilin Terhadap Micrococcus luteus dart Escherichia coil (Comparative Antibacterial Activity of 4-Methylpiperazin-N-Carbonyl Ampicillin and Arnpicillin against Micrococcus luteus and Escherichia coli)

Andreyanus Flo Pudjianto - Personal Name; Martha Ervina - Personal Name; Catherine Caroline - Personal Name; Bambang Soekardjo - Personal Name; Kuncoro Foe - Personal Name;

Piperacillin has antimicrobial action but it is not absorbed from gastrointestinal tract Therefore, it needs structure modification to increase its absorption while keeping its antimicrobial action. The 4-methy/piperazin¬N-carbonyl ampicillin was the product of reaction between ampicillin and 4-methylpiperazin-N-carbonyl chloride using Schotten Baumann method. The aim of this research was to compare the antibacterial activity between 4-methylpiperazin-N-carbonyl ampicillin and ampicillin. The comparison test of antibacterial activity was done with Kirby-Bauer disk diffusion susceptibility method on Mueller-Hinton agar which had been inoc¬ulated with Micrococcus luteus and Escherichia coll. Based on orientation studies, concentration of 4- methylpiperazin-N-carbonyl ampicillin and ampicillin were 0.5 ppm against Micrococcus /uteus and 500 ppm against Escherichia col/ in order to get visible zone of inhibition. The results showed that 4-methylpiperazin-N¬carbonyl ampicillin had lower antibacterial activity than ampicillin which was showed by its zone of inhibition which was lower compared to ampicillin in inoculated agar media of Micrococcus luteus and Escherichia coll.

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Location name is not set Jurnal Farmasi SAINS dan Terapan. 1 (1) 2013 : 9-1

A0003896

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Series Title: -
Call Number: Jurnal Farmasi SAINS dan Terapan. 1 (1) 2013 : 9-1
Publisher: Surabaya : Jurnal Farmasi SAINS dan Terapan, Univ. Katolik Mandala Surabaya., 2013
Collation: 4p
Language
ISBN/ISSN: 2338-8404
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): escherichia coli
ANTI-BACTERIAL AGENS
MICROCOCCUS LUTEUS
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Statement of Responsibility: -

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