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Expression of Tenascin in the Uterosacral Ligament is Stronger in Women with Pelvic Organ Prolapse Tenascin pada Ligamentum Sakrouterina Diekspresikan lebih kuat pada Perempuan dengan Prolaps Organ Panggul)

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Objective: This study aimed to compare the expression of tenascin uterosacral ligament in women with and without pelvic organ pro¬lapse (POP).
Methods: The research was carried out in Dr. Wahidin Sudiro¬husodo Hospital and other educational hospitals of obstetrics and gynecology division UNHAS Faculty of Medicine, which began on January 1st, 2011 until April 2012. This study assessed the expres¬sion of tenascin in 35 women with POP levels III and IV, and the con¬trols were 35 women without POP. Tenascin expression was as¬sessed by immunohistochemical examination using tenascin anti¬body staining (mouse monoclonal antibody Novacastra tenascin C, code NCL-Tenas C). The research was carried out cross sectional. Sampling was done by consecutive sampling. Data processed by the chi-square. The significance level used was 0.05.

Results: The results showed that the characteristics of research sub¬jects based on age, education, parity, labor history, history of big ba¬bies, not statistically significant. This indicates that the variable does not affect the calculation of the research data. While the charac¬teristics of menopausal status and body mass index (HMI), from the analysis of risk factors for POP is associated significantly with a higher intensity of tenascin in post-menopausal status and BMI> 25 (overweight) (p

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Indonesian Journal of Obstetrict and Gynecology, 1

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Jakarta : Puslitbang Ekologi Kesehatan,Badan Litbangkes., 2013

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5p

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2338-6401

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