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Peran Asam Lemak Omega 3 Terhadap Hipertrigliseridemia Pada Pen Derita HIV/AIDS (Role of Omega-3 Fatty Acids to Hypertriglyceridemia among HIV/AIDS Patients

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Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) patients experience various abnormal biological processes in their bodies as a result of virus infecting the CD4+ Lymphocyte T cell which causes impairment in their body immune system. One of the effects of HIV/AIDS infection and anti-retro viral therapy (HAART) is disturbance in fat metabolism which resulted in subcutaneous lipoatrophy, central accu¬mulation of fat and increase in visceral fat in absolute terms as well as relative. Results from observing HIV patients found an increase of triglycerides and a decrease of total cholesterol. However, results from AIDS patients found a decrease of High Density Lipo¬protein-Cholesterol (HDL-C), a decrease of Low Density Lipoprotein-Cholesterol (LDL-C), a decrease clearance of plasma triglycerides and an increase of Free Fatty Acids (FFA). Abnormal body composition is reported to occur among 40-50 patients infected with HIV. Omega-3 fatty acid is regarded of having very important role in cardiovascular diseases especially in managing dyslipidemia. The mechanism in which level of triglycerides is lowered by omega-3 among HIV patients is not clear but is thought due to the effect of Eicosa Pentaenoic Acid (EPA) and Docosa Hexanoic Acid (DHA) in lowering synthesis of Very Low Density Lipoprotein (VLDL) — triglycerides, increased clearance of triglycerides from VLDL particles, and / or increased conversion of VLDL remnants to LDL.

Keywords: HIV-AIDS, HAART, hypertriglyceridemia, omega-3 fatty acids

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Ketersediaan

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Judul Seri

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No. Panggil

EBER PAPYRUS, 19 (2) 2013 : 126-145

Penerbit

Jakarta : Puslitbang Farmasi, Badan Litbang Kesehatan., 2014

Deskripsi Fisik

20p

Bahasa

ISBN/ISSN

0854-8862

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Tipe Media

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