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Pengaruh Suplementasi Tepung Tempe Selama Bunting terhadap Kadar Glutathione Peroksidase (GPx) dan Malondealdehyde (MDA) Anak Tikus (Studi pada Tikus Wistar yang Mendapat Pembatasan Diet selama Bunting Effect of Tempeh Flour Supplementation During Pregnancy In Wistar Rats With Limited Diet)

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ABSTRACT
Free radicals are formed in the body as a by-product of an aerobic respiration. During pregnancy, the increase in free radicals potentially causes structural and functional damages to fetus. Tempeh is originally from Indonesia having various nutrition inclding vitamin, mineral and isoflaphon serving as antioxidhant having potential to reduce and improve DNA damage. This study was aimed to investigate the effect oftempehflour suplementation during pregnancy on Glutathione peroxides (GPx) and Malondetaldehyde (MDA) as an indicator of lipid peroxide in the offspings.

In this experimental study, 20 pregnant female wistar rats were devided into four groups of 5 rats each to receive one ofthe following treatment :10 g standard diet/rat/d, 10 g/rat/d of standard diet and tempeh flour 1. g//d, 10 g/d of standard diet and tempeh flour 2g/d, standard diet of 10 g/d and lg of egg/d. And aquades ad libitum. During nursing period (until I month)the rats were fed 10 g/100gBB/d normal diet ,after weining they were supplemented with a diet ofhigh in saturated fatfor 4 weeks for each group.

The Mean of litter size was 1:9.33 with mean of BW 4.93 g, group 11:6.17 with BW of 5.32, group III: 5.17 with BW of 5.33, group IV: 6.33 with BW 5.01. Means of GPxfor the fourgroups were 22.38 U/mg, 28.94 U/mg, 38.59 U/mg, 16.98 U/mg respectively. The mean of MDA for the four groups were 11.07 nmol/mg, 9.89 nmol/mg, 10.06 nmol/mg and 12.25 nmol/mg respectively. There was a significant difference in GPx and MDA (p=0.00). In conclusion tempeh flour had an effect on the level of GPx and MDA in rats with limited diet during pregnancy.

Keywords: Tempeh flour, Glutathione Peroksidase (GPx), Malondealdehyde (MDA)

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

SAINS Medika, 5 (1) 2013 : 38-44

Penerbit

Jakarta : FK Univ. Sultan Agung (Unisula) Semarang., 2013

Deskripsi Fisik

7p

Bahasa

ISBN/ISSN

2085-1545

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

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Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

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