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Kajian Aspek Farmakokinetik Klinik Obat Antidiabetik Pada Pasien Diabetes Mellitus Tipe 2 Dengan Gangguan Fungsi Ginjal Di Poliklinik Khusus Rsup. Dr. M. Djamil Padang (Study on Clinical Pharmacokinetic of Antidiabetics Drugs to Diabetes Mellitus Type 2 Patients with Renal Dis function in DR.M.Djamil Central General Hospital Padang

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ABSTRACT
Antidiabetic use on renal disturbance patients need to applicate principal of clinical pharmacokinetics. Decreasing renal function could distrub excretion drug and increase accumulation drug within the plasma, therefore, toxic effect will be produced and it need to adjust dose. This research aimed at studying of clinical pharmacokinetic of oral antidiabetics on diabetes mellitus (DM) type 2 patients with renal disfunction. This study was performed among DM type 2 patients with renal disfunction in policlinics DR.M.Djamil central general hospital during October 2011-January 2012 with prospective cross sectional and purposive sampling methode. Descriptive analysis based on CrCI were 1 patient in end stage renal failure, 4 patients in stadium IV, 18 patients in stadium III, 9 patients in stadium II, and 8 patients in stadium 1 (renal function is normal) with 1-15 years have gotten DM. Based on adjusting doses with renal function (Crc/ and half time elimination) were 18(45%) patients in overdose, 5(12.5%) patients in less dose, and 17(42.5%) patients in appropiate dose.

Keywords: Diabetes mellitus, renal failure, clinical pharmacokinetic

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

FARMASAINS: Jurnal Ilmiah Ilmu-ilmu Kefarmasian, 2

Penerbit

Jakarta : Jurusan Farmasi Uhamka Jakarta., 2013

Deskripsi Fisik

5p

Bahasa

ISBN/ISSN

2086-6968

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Tipe Media

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Tipe Pembawa

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