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Efek Minyak Buah Merah terhadap Ekspresi NF-1(13 pada Colitis- s-Associated Cance (The Effect of Red Fruit Oil Toward NF-Ic.B Expression on _ Colitis-Associated Cancer Mice Model

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Abstract
Introduction: Colorectal cancer has provided a paradi gm for the association between inflamma¬tion and cancer Activation of nuclear factor-k$ (NF-kB) is associated with various type of cancers due to its key role in innate immunity, inflammation, cell proliferation, and cell survival. Red Fruit (Pandanus conoideus Lam.) which contains large amount of antioxidant has been considered as phytopreventive agent. The aim of this research is to examine the effect of buah merah oil towards NF-KB expression in colitis-associated cancer (CAC) mice model.

Methods: BALB/c male mice were divided into four groups (n=6). The negative control and red fruit control groups were given aquabidest and red fruit oil, respectively, without CAC induction. The azoxymethane (A0M/dextran sulfate sodium (DSS) control and red fruit treatment groups were given A0.111followed by DSS to induce CAC. The ROA/MSS control group were given aquabidest while the red fruit treatment group were given buah merah oil. NF-tcB colon level was
measured using Western blot method Data were analyzed by One-Way ANOVA continued with Tukey HSD (a=0.05).

Result: The result showed that the average NF-x13 level of red fruit treatment group was signifi¬cantly decreased compared to the AOMDSS control group (p

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Journal of the Indonesian Medical Association (Ma

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Jakarta : Yayasan Ikatan Dokter Indonesia (IDI)., 2013

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6p

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2089-1067

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