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The Potency of Xanthones as Antioxidant and Antimalarial, and their Synergism with Artemisinin in Vitro

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Abstract
Introduction: Artemis inin in artemisinin based combination therapy (ACT) was used to over¬come the resistance caused by free radical overproduction. Xanthone as antioxidant can also inhibit in vitro heme polymerization, therefore it is predicted has anti-malaria activity. The aim of this study is to evaluate the potency of alpha mangostin, gamma mangostin, garcinone C, and garcinone D as antioxidant by determination of DPPH scavenging activity, falciparum antima¬larial, and their synergism with artemisinin as antimalarial falciparum in vitro.

Method: Diphenylpicrylhydrazyl (DPPH) scavenging activity was examined according to Unlu, et al.'s technique and the IC50 was determined by correlation regression analysis. Antimalarial activity of each xanthone and its combination with artemisinin was evaluated in P. falciparum strain 3D7 culture according to 13udimul fa, et al. Their IC50was calculated by pro bit analysis and F1050was counted according to the formula.

Results: All of these xanthones had IC „of DPPH scavenging activity

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Journal of the Indonesian Medical Association (Ma

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Jakarta : Yayasan Ikatan Dokter Indonesia (IDI)., 2013

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5p

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2089-1067

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