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Gangguan Ginjal Akut pada Pasien Demam Berdarah Dengue (Acute Kidney Injury in Patients with Dengue Hemorrhagic Fever)

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Abstract
Introduction: Dengue hemorrhagic fever (DHF) still remains an important problems of public health. Hypovolemia, which occurs, in DHF patients as well as direct impact of dengue virus to the kidney mediated by antigen - antibody reaction can precipitate manifestation of acute kidney injury (AKI). This study aims at evaluating AKI in DHF patients using pRIFLE criteria. Methods: A cross-sectional study of AKI in DHF patients was done in children who were admitted to the Wahidin Sudirohusodo, Ibnu Sina, and Islam Faisal Hospital, Makassar from September 2011 up to May 2012. All patients, confirmed byserologic examination of IgM and IgG anti dengue - rapid test, were enrolled into nonshock DHF and DSS patients.

Results: The 86 children with DHF fulfilling the study criteria consisting of 49 nonshock DHF patients and 37 DSS patients. The result of the study showed that mean serum creatinine (Scr) level in patients with DSS was 2,481 mg/dl and in nonshock DHF patients was 1,12 mg/dl; mean estimated creatinine clearence (eCC) was 20,335 ml/min/ 1,73m2 in patients with DSS and 50,351 ml/mm/1,731n2 in nonshock DHF patients; 36,05% out of all DSS patients had AKI with pRIFLE¬F whereas 17,44% and 31.39% out of all nonshock DHF patients had AKI with pRIFLE-R and I, respectively. Statistical analysis showed mean Sr level in patients with DSS was significantly higher (2,481 mg/dl) than nonshock DHF patients (1,12 mg/dl) and mean eCC value was significantly lower in patients with DSS (20,335 nil/minfi,73m2) compared to nonshock DHF patients (50,351 ml/min/1,73m2).

Conclusion: We conclude that AKI usually occurs in DSS patients as well as in nonshock DHF patients. severe AKI with pRIFLE-F was mostly found in DSS patients and AKI pRIFLE-R or I mostly encountered in nonshock DHF patients.

Key Words: DHF, DSS, AKI, creatinine serum, eCC, pRIFLE

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Journal of the Indonesian Medical Association (Ma

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Jakarta : Yayasan Ikatan Dokter Indonesia (IDI)., 2013

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6p

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2089-1067

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