Balans Cairan, Interferon-Gamma, Interleukin-12 dan Tumor Necrosis Factor Sebagai Faktor Prediksi Kesembuhan pada Sepsis Berat (Fluid Balance, Interferon-Gamma, Interleukin- 12 and Tumor Necrosis as predictive factors of Survival in Severe Sepsis | Perpustakaan dan Galeri Kebijakan Kesehatan

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Balans Cairan, Interferon-Gamma, Interleukin-12 dan Tumor Necrosis Factor Sebagai Faktor Prediksi Kesembuhan pada Sepsis Berat (Fluid Balance, Interferon-Gamma, Interleukin- 12 and Tumor Necrosis as predictive factors of Survival in Severe Sepsis

Background: The cardiovascular derangements of severe sepsis in human include arteriolar, venular dilation, capillary leak, and immunomodulatory response. Intravascular volume replacement during resuscitation most frequently converts the circulation to a high-out put hypotensive state. We hypothesized that patients with severe sepsis had any predicting factors to survive than those who do not.
Design and Method: Randomized Clinical Trials were conducted of 110 patients suffered from severe sepsis in ICU/HCU. Admission APACHE II, SOFA scores, IFN-y, 1L-12, TAW-a, and fluid balance were computed from the extracted data. Patients allowed to severe sepsis treatment according with the International Consensus Committee. Summary estimates using both the Mantel-Haenszel test and precision based approaches were computed for statistical analysis.

Result: of 110 patients ranged in age from 46 to 71 years with a mean (± SE) age of 63.45 ± 3.97 years. The mean admission APACHE II score was 25.96 ± 3.65; and the day 1 SOFA score was 9.57 ± 1.24. Twenty one patients did not survive, Non-survival had higher mean APACHE 11 than survivals (29.85 vs 20.46), respectively (p < 0.01). Higher first day IFN-y, 1L-12, TISIF-cc and SOFA scores (p< 0.01). Whereas 26 patients who achieved a negative fluid balance of > 500 mL on > of the first 3 days of treatment survived (RR 5.0; 95% C/: 2.3 to 10.7, p < 0.0001).

Conclusion: These results suggest that at least 1 day of negative fluid balance (

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A0003729

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Judul Seri: -
No. Panggil: SAINS Medika, 4 (1) 2012 :13-22
Penerbit: Semarang : FK Univ. Sultan Agung (Unisula) Semarang., 2012
Deskripsi Fisik: 10p
Bahasa
ISBN/ISSN: 2085-1545
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: SEPSIS
NECROSIS
INTERLEUKIN-12
INTERFERON TIPY II
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

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