Perbaikan Level Glutation Hipokampus Pada Tikus Yang Mengalami Penuaan Fisiologis dan Penuaan Akibat Stres Oksidatif Dengan Pemberian Alanin-Glutamin Dipeptida Improvements Glutation Levels In The Hippocampus of Aged And Oxidative-Stressed Rats By Supplementation of Alanine-Glutamine Dipeptide | Perpustakaan dan Galeri Kebijakan Kesehatan

Pencarian berdasarkan :

SEMUA Pengarang Subjek ISBN/ISSN Pencarian Spesifik

Pencarian terakhir:

Text

Perbaikan Level Glutation Hipokampus Pada Tikus Yang Mengalami Penuaan Fisiologis dan Penuaan Akibat Stres Oksidatif Dengan Pemberian Alanin-Glutamin Dipeptida Improvements Glutation Levels In The Hippocampus of Aged And Oxidative-Stressed Rats By Supplementation of Alanine-Glutamine Dipeptide

Sunarno - Nama Orang; Wasmen Manalu - Nama Orang; Nastitii Kusumorini - Nama Orang;

Background: Physiological Aging or Aging Due to Oxidative Stress Causes To Disruption of Glutathione Homeostasis of The Hippocampus. Disruption of Glutathione Homeostasis Characterized By A Decrease In Hippocampus Glutathione Levels Below The Normal Threshold. Decreased Levels of Glutathione In The Hippocampus Was Demonstrated Decreased Hippocampus Function. One Way To Increase Glutathione Levels In The Hippocampus And The Function of Hippocampus Is To Increase The Concentrations Of Glutathione Precursor. One of The Glutathione Precursors Is Alanine-Glutamine Dipeptide. This Research Was Designed to Obtain The Most Effective Level of Alanine-Glutamine Dipeptide Supplementation To Improve Glutathione Synthesis In The Hippocampus of Aged And Oxidative-Stressed Rats. The Highest Glutathione Concentrations In The Hippocampus Showed The Best Improvement on The Hippocampus Function In Physiological Aging or Oxidative-Stress Aging Rats.

Design And Methods: The Experimental Rats Were Assigned Into A Completely Randomized Design With 2x2x4 Factorial Arrangement. The First Factor Was The Age of The Experimental Rats, Consisted Of Two Levels I.E., 12 And 24 Months. The Second Factor Was Oxidative Stress Consisted Of Two Levels, I.E., Without or With Oxidative Stress. The Third Factor Was The Level Of Alanine-Glutamine Dipeptide Administration Consisted of 4 Concentrations, I.E. 0%, 3%, 5%, And 7%.

Results: The Results Showed That Administration of 7% Alanine-Glutamine Dipeptide Has Resulted The Highest Levels of Glutathione Hippocampus In Younger (0.0154 Mg/Mg Tissue) or Aged (0.0140 Mg/Mg Tissue) Rats or In Normal (0.0150 Mg/Mg Tissue) And In Oxidative-Stressed (0.0144 Mg/Mg Tissue) Rats. The Increased Hippocampus Glutathione Levels Were Associated To The Improved Functions of The Hippocampus. Conclusion: Alanine-Glutamine Dipeptide Administration of 7% Consentrations Gave The Best Results on Repair Function of The Hippocampus And Has The Potential To Slow Aging, Both Physiological Aging or Oxidative-Stress Aging Rats (Kilns Medika, 4(1):1-12).
Keywords:Alanine-Glutamine Dipeptide, Glutathione, Physiological Aging, Stress Oxidative Aging, Hippocampus Functions

Ketersediaan

Belum memasukkan lokasi SAINS Medika, 4 (1) 2012 :1-12

A0003728

Tersedia

Informasi Detail

Judul Seri: -
No. Panggil: SAINS Medika, 4 (1) 2012 :1-12
Penerbit: Semarang : FK Univ. Sultan Agung (Unisula) Semarang., 2012
Deskripsi Fisik: 12p
Bahasa
ISBN/ISSN: 2085-1545
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: rats
OXIDATIVE STRESS
HIPPOCAMPUS
GLUTATIONE
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

Versi lain/terkait

Tidak tersedia versi lain

Lampiran Berkas

Tidak Ada Data

Komentar

Anda harus masuk sebelum memberikan komentar