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Uji Sifat Fisis Gel Antiacne Ekstrak Daun Gambir (Uncaria Gambir Roxb) Dalam Basis Na CMC dan Uji Aktivitas Antibakteri Terhadap Staphylococcus Aureus

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The aim of this research is to know the influence of Na CMC concentration to physical characteristic and antibacterial activity of gel gambier leaf extract against Staphylococcus auereus. Three formulas of gel were made by various Na CMC concentration (4%, 5%, and 6%). Produced gels were tested physical characteristic (organoleptic, pH test, viscosity, homogenity, spread ability, adhesive ability, and identification of gambler leaf extract). Antibacterial activity test was done by solid diffusion method. Viscosity data was analyzed using two way ANOVA, spread ability, adhesive ability, and antibacterial activity of gel gambler leaf extract was analyzed using one way ANOVA with 95% of confidence level and continued by LSD (Least Significant Difference) on the data which had difference signifficancy. The result showed that the Na CMC concentration increases by 4%; 5%; and 6% giving impairment spread ability but increases adhesion and viscosity. The greatest antibacterial ability in gel gambler leaf extarct with a concentration 5% Na CMC.
Keywords: antibacterial activity, gel, gambler Uncaria gambir Roxb) leaf extract, Na CMC, Staphylococcus auereus

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PHARMACY: Jurnal Farmasi Indonesia, 09 (03) 2012 :

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Purwokerto : FF Universitas Muhammadiyah Purwokerto., 2012

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9p

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1693-3591

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