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Efek Penyimpanan Sediaan Pulveres Obat Anti Tuberkulosis (OAT) Anak Terhadap Kadar Rifampisin dan Isoniasid

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On the treatment of children with tuberculosis, doctor often prescribes anti-tuberculosis drug (OAT) for children in combination and make it pulveres preparation which is aimed to increase patient's obedience and regularity in consuming medicine. However, the medication employing more than one form of drugs which was combined into one form of certain preparation may trigger instability of the drugs itself.
This research was aimed to determine the changes of physical stability and the decreasing level of rifampin and isoniasid in pulveres preparation of OAT mixture during the storage on room temperature. The method employed in this research was experimental with one group pretest posttest research proposal and the data analysis method was one way an ova. During one-month storage, there were no changes on the physical stability of OAT pulveres preparation i.e. it remained dry, reddish, and distinctive smell. However, the level of rifam pin and isoniasid which was the component of pulveres preparation ofOAT decreased. The average level of rifampin storage on day zero was 102.51%; day 7 was101.88%; day 14 was97.36%, day 21 was95.19%, day 28 was 93.04%. Whereas, the average level of isoniasid storage on day zero was104.66%; day 7 was103.35%; day 14 was94.55%; day 21 was 93.75%; day 28 was 92.69%. The statisticresult showed that there was a significant distinction(p

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PHARMACY: Jurnal Farmasi Indonesia, 09 (03) 2012 :

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Purwokerto : FF Universitas Muhammadiyah Purwokerto., 2012

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8p

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1693-3591

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