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Aktivitas Spesifik Manganese Superoxide Dismutase (Mnsod) dan Katalase pada Hati Tikus yang Diinduksi Hipoksia Sistemik: Hubungannya dengan Kerusakan Oksidatif Spesific Activity of Manganese Superoxide Dismutase (MnSOD) and Catalase in the Rat Liver Induced Systemic Hypdxia : Relationship with Oxidative Damage}

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MnSOD and catalase are endogeneous antioksidants which function to neutralize five radicals. Oxydative stress causes oxidative damage which can be measured by elevated levels of Malondialdehyde (MDA) in the cells. Chronic systemic hypoxia is a condition caused by a systemic decrease in oxygen intake in the long term. This condition can cause oxidative stress that result in oxidative damage to cells in various tissues. Our previous study proved that there are different responses in different rat tissues induced chronic systemic hypoxia.

The objective of this study was to analyze specific activity of MnSOD and catalase in mouse liver tissue induced with systemic hipoksia and their association with oxidative damage. Sample in this research is male mouse liver tissue from Sprague Dawley strain (Rattus novergicus L), induced with chronic systemic hypoxia for 1,7,14 and 21 days. Mouse liver homogenate tested for specific activity of MnSOD, katalase and 1WDA.

Data showed a decline in specific activity of MnSOD and catalase are significant (p

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Media Penelitian dan Pengembangan Kesehatan, 22 (2

Publisher

Jakarta : Sekretariat Badan Litbangkes., 2012

Collation

6p.

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ISBN/ISSN

0853-9987

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Subject(s)

rats
HEART

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