Identification of safety of alert by monitoring analytical parameters and high-risk drugs | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Identification of safety of alert by monitoring analytical parameters and high-risk drugs

Vicente Escudero-Vilaplana - Personal Name; Maria Gomez-Antanez - Personal Name; Esther Duran-Garcia - Personal Name; Antonio Muhio-Miguez - Personal Name; Maria Sanjurjo-Saez - Personal Name;

Early detection of adverse drug reactions (ADR) increases patient safety. Our objective was to identify ADR by monitoring laboratory parameters and high-risk drugs. We carried out a two-month prospective observational study in a Internal Medicine Department, with daily recording of drugs prescribed and the following parameters: Na, K, Ca, serum creatinine, glomerular filtration rate (GFR), INR, glucose, haemoglobin, platelets, ALT, AST, bilirubin, GGT, alkaline phosphatase, TSH, T4, and blood digoxin. High-risk drugs were closely monitored. 52 patients included, of whom 46.2% experienced an ADR. We observed an association with drugs in 25.5%, as follows: reduction in GFR, 26.9% (associated with loop diuretics [41.7%], angiotensin-converting enzyme [ACE] inhibitors [33.3%], angiotensin II receptor blockers EARS] [16.6%], and anti-diabetic drugs [8.3%]); hypokalemia, 22.3% (associated with loop diuretics [50.0%], potassium-free fluid [37.5%], and salbutamol [12.5%]); hyperkalemia, 14.4% (associated with ACE inhibitors [60.0%] and ARB [40.0%]); INR out of range, 10.8% (associated with drug interactions [66.7%]); hyperglycemia, 8.1% (associated with corticosteroids [66.7%] and anti-diabetic drugs [33.3%]); and other conditions, 18.8%. We conclued that patient safety could be improved by implementing warnings in electronic prescriptions in cases of a decrease in GFR or modification of potassium levels in patients who are prescribed loop diuretics, ACE inhibitors, or ARBs.
Key words: Adverse drug reaction, clinical decision support, high-risk drug, safety

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Location name is not set Majalah Farmasi Indonesia, 23 (2) 2012 : 130-134

A0003698

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Series Title: -
Call Number: Majalah Farmasi Indonesia, 23 (2) 2012 : 130-134
Publisher: Yogyakarta : Faculty of Pharmacy Universitas Gajah Mada Yogyakarta., 2012
Collation: 5p
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ISBN/ISSN: 0126-1037
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Subject(s): drugs
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