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Passive and iontophoretic permeation of captoril gel: an in vitro and in vivo study

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The Objective of this work was to formulate and evaluate captopril gel to assess its suitability for transdermal delivery by passive and iontophoresis. A polymer gel was prepared using hydroxypropyl methyl cellulose and in vitro skin permeability was assessed in full thickness skin of rabbits and pigs. For in vivo studies New Zealand rabbits were used. In vitro passive permeation was carried out in Franz diffusion cell but for iontophoresis, diffusion cell was modified according to Glikfield design. Iontophoresis was performed at a current density of 0.5 mA/cm2 via silver /silver chloride electrodes with passive controls but for in vivo study current density was reduced to 0.1 mA/cm2. Blood samples were analyzed for drug content by HPLC. Results of the in vitro study indicated that iontophoresis considerably increased the permeation rate of captopril compared to passive controls in both the skin types (P

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Detail Information

Series Title

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Call Number

Majalah Farmasi Indonesia, 23 (2) 2012 : 121-129

Publisher

Yogyakarta : Faculty of Pharmacy Universitas Gajah Mada Yogyakarta., 2012

Collation

9p

Language

ISBN/ISSN

0126-1037

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

CAPTOPRIL
IONTOPHORESIS

Specific Detail Info

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Statement of Responsibility

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