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Virulensi dan Transmisi Virus Influenza A pada Manusia, Hewan Mamalia dan Unggas (Virulence and Transmission of Influenza Virus Type A among Human, Mammals and Birds)
In the 20th century, influenza virus A infections caused the pandemic severe respiratory illness in humans, some of the cases were fatal. Therefore, it is important for us to know the transmission mechanism and factors that can affect the virulence of influenza viruses. Virulence of influenza virus in birds, mammals and humans is determined by its ability to inflict damage to host cells caused by the eight genes in the virus. Eight of these genes have different tasks and functions that need to be analyzed. Besides knowing the virulence of influenza virus, should also know the transmission mechanism of these viruses. Influenza type A virus in poultry (called avian influenza) can transmit directly from birds to humans that can cause fatal infections. Understanding of the factors that play a role in the transmission between species of birds, mammals and humans can help the development of surveillance strategies to determine rapidly the potential strain of influenza A virus that can cause a pandemic.
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