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Quercetin causes to decrease proximal tubules apoptotic cells in streptozotocin-induced deabetic RAT

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Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Wistar male rat (n=40) were allocated into three groups, control group (n=10) and quercetin (QR) group that received 15mg/kg (IP) QR, (n=10), and Diabetic group that received 55mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10; STZ group and treatment group. Treatment group received 55mg/kg (IP) STZ plus 15mg/kg QR, daily for 4 weeks, respectively; however, the control group just received an equal volume of distilled water daily(IP) . Diabetes were induced by a single (IP) injection of streptozotocin (55mg/kg). Animals were kept in standard condition. In 28 day after inducing diabetic 5 mL blood were collected for Total Antioxidant Capacity (TAC), Malondi Dehyde (MDA) and Oxidized Low density Lipoprotein (Ox-LDL) levels and kidney tissues of Rat in whole groups were removed then prepared for Apoptosis analysis by Tune! metho. Apoptotic cells significantly decreased in group that has received 15mg/kg (IP) quercetin (P

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Detail Information

Series Title

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Call Number

Majalah Farmasi Indonesia, 23 (3) 2012 : 156-161

Publisher

Yogyakarta : Faculty of Pharmacy Universitas Gajah Mada Yogyakarta., 2012

Collation

6p

Language

ISBN/ISSN

0126-1037

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

DIABETES MELITUS
STREPTOZOCIN

Specific Detail Info

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