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Dampak Defisiensi Iodium Maternal pada Persistensi Disfungsi Neuropsikologis Anak Usia 12 Tahun (Effect of Maternal Iodine Deficiency on The Persistence of Neurological Dysfunctions In Children Aged 12 Years)

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Study on the last effect of neuropsychologic dysfunction due to iodine deficiency during gestation is still scarce. This study is to confirm the persistence of neuropsychological dysfunctions at 12-year-old of children born from pregnant mothers with iodine deficiency in endemic iodine deficient area. The study is 13-year-cohort design. Iodine status (Total T4, TSH and UIE) of pregnant mothers at initial study, neonatal (TSH) and 12 year-old iodine status (fT4, TSH) are performed. Neurological dysfunction of infants is examined every 6 weeks until the child age is 24 months. Neuropsychological dysfunction of children 12 years of age such as minimal brain dysfunction and psychological battery of Wechsler Intelligence Scale for Children (WISC) are also administered. A screening to determine case and reference using is done using mini mental status examination (MMSE). Score MMSE of 28 or less are implemented as cases while others as reference. The relationship of neurological and cognitive dysfunction with both maternal iodine status and neurological dysfunction at 2 months of neonates age are elaborated. The persistency risk of neurological dysfunction at 12 years of age is 8% (95%ci: 1-15%). Maternal and neonatal iodine status (as indicated by TSH, T4) are the risk factors for the persistency at 12-years. However, delays of neurological development in two-month old infants are found as directly risk factors. Median Total IQ score for all participants are far lower than the lowest limit of normal range. A very significant difference (p=0.000) are found in Total IQ score between cases and references. Discrepancy analysis of IQV-IQP indicates brain lesions in subtle form, such as diadokhokinesis, praxis, memory, distractibility and lowered IQ score. Neuropsychological dysfunctions due maternal iodine deficiency are still persistence at 12 years. Maternal T4 during gestation is not only influences on the persistency but also impaires directly on the brain development of the progeny. Maternal TSH influences on neuropsychomotor development of infant only.

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Series Title

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Call Number

Penelitian Gizi dan Makanan, 35 (1) 2012: 23-33

Publisher

Bogor : Puslitbang Gizi, Badan Litbang Kesehtan., 2012

Collation

11p.

Language

ISBN/ISSN

0125-9717

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Edition

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Subject(s)

child
IODINE-deficiency
MATERNAL
NEUROPSYCHOLOGY

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