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Studi Pemanfaatan dan Keamanan Kombinasi Metformin dengan Ekstrak Campuran Andrographis Paniculatadan Syzygium Polyanthum untuk Pengobatan Diabetes Mellitus (Preliminary Study)

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Background: Use of Andrographis paniculata and Syzigium polyanthum have been used widely, on the contrary the benefit and safety have not been scientifically proven. This study aimed to overview and analyze benefit and safety the extract of Andrographis paniculata and Syzigium polyanthum mixture to decrease blood glucose concentration.
Methods: It was an experiment study among intervension and control groups by a block random sampling with pre-post test design. Data were collected by questionnaires and also data among intervension group, therapy of conventional antidiabetic of metformin in combination to the herbal extract of Andrographis paniculata and Syzigium polyanthum mixture (1: 1) with among control group, of metformin. A total samples of 30 Diabetes Mellitus respondents were selected among males or females, aged 40-60 years with blood glucose concentration of 140-220 mg/dl, has no history of hypertension or has mild hypertension.
The samples were devided in 2 groups composed of 15 persons among intervsion and 15 persons among control groups, respectively The intervension group was given metformin 500 mg once a day in the morning taken 15 minutes after breakfast in combination to the extract of Andrographis paniculata and Syzigium polyanthum mixture (1: 1) of 700 mg.
The control group was given metformin 500 mg on ce a day in the morning taken 15 minutes after breakfast in combination to placebo. The duration of therapy was 4 weeks. Data were taken by anamnesa, physical diagnose, laboratory examination offasting blood glucose and Oral Glucose Tolerance Test (OGTT) in every week. Meanwhile for examination side effects on liver and run function test in every 2 (two) week. The data were analyzed descriptively and t test.
Results: Results showed that the intervension group given metformin in combination to the extract of Andrographis paniculata and Syzigium polyanthum mixture (1:1) of 700 mg could significantly decrease fasting blood glucose but could not significantly decrease OGTT in comprasion to control group given metformin with placebo.
There were no side effects on liver and kidney function test in the therapy of herbal extract of Andrographis paniculata and Syzigium polyanthum mixture in duration of 4 we eks. It concluded that the herbal extract of Andrographis paniculata and Syzigium polyanthum mixture is safe.

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Series Title

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Call Number

Buletin Penelitian Sistem Kesehatan, 15 (2) 2012:

Publisher

Surabaya : Pusat Humaniora, Kebijakan Kesehatan dan Pemberdayaan Masyarakat., 2012

Collation

10p

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ISBN/ISSN

1410-2935

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Edition

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Subject(s)

plants, medicinal
plant extracts

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