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Sebaran Serotipe Virus Dengue di Pontianak, Medan dan Jakarta Tahun 2008

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Background:The severity of clinical manifestation of dengue infection depends on the 4 virus serotypes. The aim of the study is to explore the distribution of dengue virus serotypes in 3 cities (Pontianak, Medan and Jakarta) in 2008.
Methods: The study was across-sectional designed; data were obtained from each 2 hospitals in Pontianak, Medan and Jakarta. Sera samples were collected from patients visiting internal and pediatric units in the hospital, whicn met the inclusion criteria, i.e. had fever for 2 - 7 days, with hemorrhagic manifestation, and/or thrombocyte level less than 100.00/mm3, haematocrit >20% , and had informed-consent signed. Sampie sizes were 90 patients from each hospital. About 5 mL blood samples were collected, and serum were separated for RT¬PCR testing to determine virus serotype.
Results: About 244 sera were collected, i.e. 95 serafrom Pontianak, 86 sera from Medan, and 65 sera from Jakarta. Patients visiting hospital mostly had fever for 4 days. More than 60% of RT-PCR tested sera were dengue positive; with the serotype composition Den-3, Den-2 and 3, Den-3 and 1, respectively in Pontianak, Medan and Jakarta.
Conclusion: Four dengue virus serotype circulated in Pontianak, Medan and Jakarta, with the majority of serotype 3 (Den-3) in Pontianak and Jakarta, and serotype 2 (Den-2) in Medan.
Key words: DHF, dengue, sero type,
Infeksi Virus Dengue Tanpa (Santya, RNRE. ef al)

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Series Title

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Call Number

Jurnal Biotek Medisiana Indonesia, 1(2) 2012 : 63-

Publisher

Jakarta : Pusat Biomedis dan Teknologi Dasar Kesehatan., 2012

Collation

6p

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ISBN/ISSN

2301-5810

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Edition

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Subject(s)

DENGUE VIRUS
DENGUE HEMORRHAGIC FEVER

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