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Serum Bile Acid: an Alternative Liver Function Marker in the Obstructive Jaundice Patient

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Aim: to confirm the role of bile acid value as single marker for liver function test as compared to the conventional liver function tests on obstructive jaundice patients. Methods: before and after study on severe obstructive jaundice patients was performedfrom December 2007 until January 2009. The liver function markers were measured before, 7th day and 14th day after bile duet decompression (BDD). Open Cholecystostomy as BDD was used as a model to observe the markers changes. Samples were collected by trained medical professionals and Automated clinical chemistry analyzer (ACA) TRX 7010 was used to measure the markers value. All continuous data were presented as mean (SD) and the variables were compared and analyzed by t-test and multiple measurements test using SPSS v.16 with ap-value of < 0.05 considered to be statistically significant.
Results: twenty one patients were included. All patients suffered bile acid accumulation and impairment of all conventional liver functions tests. After decompression, the average serum bile acid decreased significantly (p

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Acta Medica Indonesiana: The Indonesian Journal of

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Jakarta : FK universitas indonesia., 2012

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6p

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0125-9326

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