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Bone Marrow Involvement by Lymphoproliferative Disorders Post Liver Transplantation: PTLD Int Survey
Aim: to analyze cases of BM PTLD in liver trans plant recipients to find any specific predictor or prognostic factor associated with this disease localization. Methods: a comprehensive search of the existing literature was performed, and 173 liver recipients who had developed PTLD in their post trans plant course from 19 studies were found and enrolled into analysis. 36 of the patients were BM PTLD cases and the remaining was used as controls.
Results: liver trans plant recipients with BM PTLD were significantly more likely to represent in male patients (p=0.042) and the elderly (p=0. 08). BM PTLD was significantly more likely to complicate liver allograft (p=0.027) and spleen (p=0.013). Histopathological evaluations showed that BM PTLD lesions were more likely ofmonomorphic type (p=0.025). Multi-organ and disseminated PTLD were significantly more pff:valent among BM PTLD patients (p
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