60. Ekstrak Phyllanthus niruri Linn, Pertumbuhan Tumor dan Proliferasi Sel Kanker Kolorektal:Studi Eksperimental pada Tikus Sprague-Dawley yang Diinduksi 1,2 DMH (Effect of Phyllanthus niruri Linn extract on tumor growth and cell proliferation of colorectal cancer:experimental study in 1.2 DMH-induced Sprague-Dawley rats) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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60. Ekstrak Phyllanthus niruri Linn, Pertumbuhan Tumor dan Proliferasi Sel Kanker Kolorektal:Studi Eksperimental pada Tikus Sprague-Dawley yang Diinduksi 1,2 DMH (Effect of Phyllanthus niruri Linn extract on tumor growth and cell proliferation of colorectal cancer:experimental study in 1.2 DMH-induced Sprague-Dawley rats)

Endang Sawitri - Personal Name; Tjahjono - Personal Name; Edi Dharmana - Personal Name; Ing. Riwanto - Personal Name;

Background: The development of chemotherapy for colorectal cancer (CRC) is so very advanced, however, the survival of patients has not been satisfactory, therefore, the current therapy also involve immunotherapy. Phyllanthus niruri Linn (P. niruri L) may act as an immunomodulator and anticancer, but its potency has not been revealed. Study was conducted to confirm the ejJects of P. niruri L extract in the treatment of CRC.
Method: The study was randomized posttest-only control group design. Samples were Sprague-Dawley male rats, bodyweight 170- 220 gr, were divided into two groups: non induced or negative control (K-) consisted of 9 normal rats, and induced by 1.2 DMH 30 mg/kgBW subcutaneously group consisted 30 rats. On the weeks 9, 11 and 13, four induced rats each week were sacrified to detect the development of CRC. On the weeks of 13th all of 4 rats were developed CRC, so the induction were stopped. The rest of 18 induced rats were randomly into two groups: without P. niruri L or positive control (K +)=9 rats and given P. niruri L extract 13.5 mglkg orally or X group=9 rats. After 19th week all of rats were then terminated and tumor lesion of colon were examined macroscopically and hystophatologic tissues were stained with AgNORs for evaluate the cells proliferation. Oneway Anova and Post Hoc LSD test for the growth of colon tumor and non pairs t-test for cell proliferation were used. Considered significant if p was

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Location name is not set Media Medika Indonesiana, 46 (1) 2012 : 25-32

A0003424

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Series Title: -
Call Number: Media Medika Indonesiana, 46 (1) 2012 : 25-32
Publisher: Semarang : FK Diponegoro Semarang., 2012
Collation: 8p
Language
ISBN/ISSN: 0126-1762
Classification: -
Content Type: -
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Edition: -
Subject(s): anticarcinogenic agents
COLORECTAL, NEOPLASMS
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Statement of Responsibility: -

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