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The Effect of Polymorphisms of Estrogen Receptor βRS1271572 to the Incidence of Epithelial Ovarian Carcinoma (Pengaruh Polimorfisme Reseptor Estrogen βRS1271572 Terhadap Kejadian Karsinoma Epitel Ovarium
Objective: To determine the effect of polymorphism of estrogen re¬ceptor ~ to the risk of epithelial ovarian carcinoma at Dr. Mohammad Hoesin Hospital Palembang
Methods: This population-based case control study included 40 women with epithelial ovarian carcinoma and 40 controIs, from January 2010 until December 2011. Data analysis was performed by Chi Square test
Results: Distribution of estrogen receptor beta genotypes, both GT and 11 (wild type-mutant and mutant), among case subjects was significantly higher than control (24 subjects {60%} vs. 5 subjects {12.5%}). The genotype effect was statistically significant for rs1271572 (OR=2.636; p=0.039) with Chi Square analysis. Whereas the allotype effect was also statistically significant (OR=1.949; p= 0.047).
Conclusion: Polymorphism of estrogen receptor β may play a role in the risk of epithelial ovarian carcinoma at Dr. Mohammad Hoesin Hospital Palembang.
Keywords: epithelial ovarian carcinoma, polymorphism of estrogen receptor β risk factor of ovarian carcinoma
A0003412 | Indonesian Journal of Obstetrics and Gynecology, 3 | Available |
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