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Phytoestrogen Genisteln and Black Cohosh and Marker of BMD in Menopausal Women (Fitoestrogen genistein dan black cohosh dan penanda BMD pada perempuan menopause)

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Background: In Indonesia, phytoestrogens can be found in the market as supplement to resolve climateric osteoporosis. This phytoestrogens has not been proven scientifically to have benefit in overcoming th climacteric ( osteoporosis in menopausal women. Therefore, it is important to have clinical test searching data for knowing the in mineral density (BMD).
Methods: The design was comparison clinical test in the form of "add on" with double blind in Hospital of Mohammad Hoesin Palembang started in August 2010 until February 2011 putting subjects into fitoestrogen and placebo groups randoi spine and femur were measured using done densitometry before and after 6 months supplementation.
Results: In the beginning of study, it was found that the average of spine T-score in the group of phy to. -1.455±0.264 after 6 months it increased to -1.295±0.223 with change 0.160±0.153 (p =0. 001). Whereas in placebo gro. of spine T-score at the beginning of the study was -1.295±0.223 becoming -1.560±0.414 with decrease of -0.1 00±0273 (p=0.118). Femur T-score level, ofphytoestrogens group at the beginning of the study was -1.415±0,215, after 6 months it became with change of 0.145±0.170 (p=0.001). In placebo group, the average offemur T-score was -1.475±0.202 becoming with of decrease -0. 120±0.33 (p=0.124). The status of spine and femur T-score BMD both in, phytoestrogens and plac, osteopenia at the beginning of the study. After 6 months, spine T-score in phytoestrogens group did not change, a group, 2 subject showed osteoporosis with 'spine T-score andfemur T-score -2.7 and -2.75(±0.212).
Conclusions: The administration of phytoestrogens is able to maintain bone mineral density and prevent the osteoporosis.
Keywords: Phytoestrogens, BMD, T-score, menopause

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Media Medika Indonesiana, 46 (2) 2012 : 132-137

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Semarang : FK Diponegoro Semarang., 2012

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6p

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0126-1762

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