Suplementasi Folate, Kadar Homocysteine, Nitric Oxide dan Petanda Retinopati Diabetik Studi pada Tikus Sprague Dawley Diabetes (Folate supplementation homocysteine, nitric oxide levels and marker for diabetic retinopathy: Study on Sprague Dawley diabetic rats | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Suplementasi Folate, Kadar Homocysteine, Nitric Oxide dan Petanda Retinopati Diabetik Studi pada Tikus Sprague Dawley Diabetes (Folate supplementation homocysteine, nitric oxide levels and marker for diabetic retinopathy: Study on Sprague Dawley diabetic rats

Banundari Rachmawati - Personal Name;

Introdnctlon: Diabetic retinopathy (DR) is the leading cause of blindness among diabetes mellitus (DMJ patients. Hyperhomocysteinemia (HHcy) is reported to increase the risk for DM complications, however, the underlying mechanism is still unclear. Retina is particularly vulnerable to oxidative stress due to a high demand for oxygen. Hyperglycemia stimulates retinal oxidative stress and increases Nitric Oxide (NO). NO contributes to the regulation of retinal blood vessel function and the occurrence of retinopathy. The administration of folic acid (FA) 0.65 mg/day on HHcy subject, decrease serum Hey by 42%. This study was aimed to analyze the effect offolate administration on Hey, NO levels and markers of DR (VEGF serum).
Methods: An experimental study using a randomized controlled group pretest posttest design was conducted in UGM Yogyakarta. The total of 40 male Sprague Dawley rats were divided into 5 groups: negative control and the other four group were induced with Streptozotocin 40 mg/kgBW intraperitoneal. Intervention group were given FA 2, 4, 8 ppm through a nasogastric tubefor 30 days. Before and after intervention, serum Hey, NO and VEGF were assessed, and Wilcoxon tests were used to measure the difference of it. Result: Administration of 8 ppm FA significantly decreased serum Hey (p=0.043), NO levels (p=0.043) but notfor markers of DR.
Conclusion: Folic acid supplementation of 8 ppm gives benefits to diabetic rats.
Keywords: Diabetic retinopathy, homocysteine, NO, VEGF

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Location name is not set Media Medika Indonesiana, 46 (2) 2012 : 100-107

A0003379

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Series Title: -
Call Number: Media Medika Indonesiana, 46 (2) 2012 : 100-107
Publisher: Semarang : FK Diponegoro Semarang., 2012
Collation: 8p
Language
ISBN/ISSN: 0126-1762
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): HOMOCYSTEINE
NITRIC OXIDE
DIABETIC RETINOPATHY
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Statement of Responsibility: -

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