Pajanan Pestisida Sebagai Faktor Risiko Hipotiroidisme pada Wanita Usia Subur di Daerah Pertanian (Pesticide exposure as a riskfactor for hypothyroidism in womef? at childbearing age in agricultural areas | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Pajanan Pestisida Sebagai Faktor Risiko Hipotiroidisme pada Wanita Usia Subur di Daerah Pertanian (Pesticide exposure as a riskfactor for hypothyroidism in womef? at childbearing age in agricultural areas

Suhartono - Personal Name; Suratman - Personal Name; Suharyo Hadisaputro - Personal Name; Apoina Kartini - Personal Name; RRJ Sri Djokomoeljanto - Personal Name; Hertanto Wahyu Subagio - Personal Name;

Background: Hypothyroidism in women at childbearing age (WCA) will cause reproduction disorder, i.e. infertility, spontaneous abortion, impaired growth and development of foetus, placental abruption, and preterm delivery. Pesticide exposure is suspected to cause hypothyroidism. The research objective is to prove that pesticide exposure is a risk factor for hypothyroidism among WCA in agricultural areas.
Methods: Case-control studies were used as study designs. Study subjects were 44 WCA as cases and 45 WCA as controls. Pesticide exposure was measured by asking WCA 's involvement in agricultural activities using structured questionnaire and by checking their levels of cholinesterase. Hypothyroidism was determined based on the results of TSH, FT4, and T3 level. Confounding variables were also measured. These variables were age, body mass index (BMI), participation in hormonal contraception, liver function, urinary iodine excretion, urinary thiocyanate level and blood lead level. Chi-square test, OR (95% CI), and multivariate logistic regression were implemented to test the hypothesis.
Results: Pesticides exposure is a risk factor for hypothyroidism (crude-OR=3.04; 95% CI=1.20-7.81; nilai p=0.033 and adjusted OR=3.31, 95% CI=1.25 to 8.78, p=0.016). The higher the degree of exposure, the greater the risk ofhaving hypothyroidism. Conclusion: Pesticides exposure is a riskfactor for hypothyroidism among WCA in agricultural areas.
Keywords: Pesticide exposure, riskfactor, hypothyroidism, women at childbearing age, agricultural area

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Location name is not set Media Medika Indonesiana, 46 (2) 2012 : 91-99

A0003378

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Detail Information

Series Title: -
Call Number: Media Medika Indonesiana, 46 (2) 2012 : 91-99
Publisher: Semarang : FK Diponegoro Semarang., 2012
Collation: 9p
Language
ISBN/ISSN: 0126-1762
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): women
hypothyroidism
PESTICIDES
Specific Detail Info: -
Statement of Responsibility: -

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