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Photodynamic Therapy As an Adjuvant Therapy for Local- Partial Remission of Nasopharyngeal Carcinoma After Standard Therapy in Sardjito Hospital Yogyakarta A Five- Year-Overall Survival Rate Analysis Study (Photodynamic therapy sebagai terapi ajuvan karsinoma nasofaring remisi lokal-parsial setelah terapi standar di RSUP Dr. Sardjito Yogyakarta: Studi analisis angka kehidupan lima tahun

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Background: The foremost problems of nasopharyngeal carcinoma (NPC) management are high loco-regional remission, local recurrence and spreading rate post therapy. Photodynamic therapy (PDT) has been done for treatment of tumors less than 1 cm in size and depth in a very diffzcult location, where radical excision by surgery was not possible. The aim of th is study is determining 5-year-overall survival rate of local-partial remission of NPC after standard therapy followed by additional PDT.
Method: The survival study is subjected to the 5 years-overall survival rate of local-partial remission. Photosensitizer (FoscanR) 0,15mg/kgBW was injected to NPC patients and followed by 20 joule/cm2, 642 wave length and 100 watts/cm2 irradiants non thermal laser illumination 96 hours after injection. The PDT result was confirmed with biopsy, CT scan, upper abdominal USG, thoracic radiograph and bone survey for 12 weeks after treatment. Follow up was done every 3 months in first year, continued every 6 months in the second year, andfollowed once a year. The sampie collectedfrom January 2005 to December 2010, and 33 cases met the inclusion and exclusion criterias, but only 20 cases were eligible inclusion criteria. The 5 years-overall survival was defined as the time from diagnosis to death from any cause or last follow up, calculated by Kaplan Meier survival analysis. Results: The 5-year-overall survival rate was 50%.
Conclusion: PDT as an additional treatment for small local-partial remission in NPC post treatment is an alternative therapy to improve the treatment outcome and survival rate.
Keywords: NPC, PDT, 5-year-survival rate

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Media Medika Indonesiana, 46 (2) 2012 : 86-90

Penerbit

Semarang : FK Diponegoro Semarang., 2012

Deskripsi Fisik

5p

Bahasa

ISBN/ISSN

0126-1762

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

nasopharyngeal neoplasms
PHOTOCHEMOTHERAPY

Info Detail Spesifik

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Pernyataan Tanggungjawab

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