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Polymorphism of vascular endhothelial growth factor (VEGF) gene insertion/deletion -2549 as risk factor of diabetic retinopathy in Javanese patients with type 2 diabetes

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Diabetic retinopathy (DR) is a visual disorder caused by the diabetic microvascular complications. Genetic polymorphism in the vascular endothelial growth factor (VEGF) gene plays an important role in the susceptibility of DR. The aim of this study was to evaluate the association of the polymorphism of VEGF gene insetion/deletion (I/D) -2549 with DR in Javanese type 2 diabetes mellitus (DM) patients. This was a ca se control study involving 40 Javanese type 2 DM patients with DR as case subjects and 40 Javanese type 2 DM patients without DR as control subjects. Type 2 DM patients with DR were recruited from Eye Polyclinic, whereas type 2 DM patients without DR were recruited from Endocrine Polyclinic of Dr. Sardjito General Hospital, Yogyakarta. Genotyping of VEGF gene I/D-2549 was conducted using PCR-RFLP method. Plasma VEGF levels were measured using enzym-linked immunosorbent assay (ELISA) . The genotype distribution of DD (67.5%) and the al lele frequency of D (82.5%) in type 2 DM patients with DR were higher than those without DR (27.5% for DD genotype and 56.3% for Dallele). The OR of DD and ID genotypes versus II genotype between type 2 DM patients with DR and without DR was 6.882 (95 %CI: 0.789-60.060; p = 0.048), whereas OR for the Dallele versus l allele between type 2 DM patients with DR and without DR was 3.667 (95% CI: 1.773-3.667; p = 0.000). The plasma VEGF levels of DD genotype (92.16 ± 49.73 pg/mL) were significantly higher than ID genotype (42.70 ± 33.29 pg/mL) in type 2 DM patients (p =0.000). In conclusion, the polymorphism of VEGF gene I/D -2549 is associated with DR in Javanese type 2 DM patients. The DD genotype and D allele of the VEGF gene polymorphism are the risk factor of DR in those patients. The association of the polymorphism of VEGF gene with DR may be explained with the high plasma VEGF level.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Journal of the Medical Sciences, 44 (2) 2012 : 239

Penerbit

Yogyakarta : FK Universitas Gajah Mada Yogyakarta., 2012

Deskripsi Fisik

9p

Bahasa

ISBN/ISSN

0126-1312

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

POLYMORPHISM, GENERIC
DIABETIC RETINOPATHY

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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