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The association of single nucleotide polymorphism (SNP) rs2922126 within ghrelin and growth hormone secretagogue receptor 1 a (GHSR1a) gene with insulin resistance in obese female adolescents in Yogyakarta Special Region

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Previous study reported th at among 79 obese female adolescents in Yogyakarta Special Region, 44 (55.7%) of th em have insulin resistance. However, no significant differences on dietary habits and physical activity between the obese female who have insulin resistance and those who are insulin sensitive were observed. Therefore, it was thought that genetic factors are involved in the occurrence of insulin resistance. Ghrelin and growth hormone secretagogue receptor (GHSR) genes have been associated with the insulin signaling pathway with implications in insulin resistance. The study aimed to analyze the association between SNP (single nucleotid polymorphism) rs2922126 in GHSRl a gene with insulin resistance in obese female adolescents in Yogyakarta Special Region. Seventy eight obese female adolescents who were selected in the previous study were involved in this study. Secondary data including name of subjects, age, body height, body weight, BMI (body mass index), fasting glucose level, fasting insulin level, waist circumference and HaMA-IR index were obtained from previous study. Polymerase Chain Reaction. (PCR) and Restriction Fragment Length Polymorphism (RFLP) methods were used to the genotype analysis of SNP rs2922126. Chi-square test was us ed to calculate odds ratio on genotype and allele of SNP rs2922126 GHSR 1 a gene in insulin resistance and insulin sensitive groups.
The results showed that AlA genotype individuais in SNP rs2922126 had higher risk to develop insulin resistance, compared to AIT and TIT genotypes individuais (OR: 2.03; 95%CI: 0.54-7.57). However, it was not significantly different (p>0.05). Individuais with AlA genotype and A allele carriers at SNP rs2922126 tended to have a higher value of BMI, fasting glucose level, fasting insulin level, HaMA-IR, and waist circumference compared to other carriers, although it was not significant (p>0.05). It can be concluded th at SNP rs2922126 in GHSR1a gene is not associated with insulin resistance in obese female adolescents in Yogyakarta Special Region.

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Detail Information

Series Title

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Call Number

Journal of the Medical Sciences, 44 (2) 2012 : 231

Publisher

Yogyakarta : FK Universitas Gajah Mada Yogyakarta., 2012

Collation

7p

Language

ISBN/ISSN

0126-1312

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

obesity
INSULIN RESISTANCE
POLYMORPHISM, SINGE NUCLEOTIDE

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