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Efficacy of ketamine gargle 40 mg and benzydamine Hei 0.075% in reducing post intubation sore throat

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Sore throat is a frequent complication in postoperative patients under general anesthesia which is performed with endotracheal tube intubation. This effect occurs because of mucosal irritation and damage and airways inflammation due to a lubricant gel on laryngoscopy or an em ph as is of endotracheal tube cuff. This study was conducted to compare the efficacy of ketamine 40 mg gargle with benzydamine HCI 0.075% gargle in reducing post intubation of sore throat prior to the insertion of endotracheal tube.
A prospective randomized double blind control led clinical trial enrolled patients aged 18-50 years with physical status of ASA I and II who underwent elective surgery with general anesthesia in Dr. Sardjito General Hospital, Yogyakarta. Subjects were divided into 2 groups. 50 patients of group A were given 30 mL ketamine gargle 40 mg and 51 patients of group B were given 30mL benzydamine HCI gargle 0.075%. The sore throat was measured whenever the patients were fully awake, 2 hours and 4 hours post-extubation with Can bay score (no pain, mild pain, moderate pain and severe pain). There was a significant difference (p < 0.01) in sore throat incidence of both groups especially at fully awake and 2 hours post-extubation; 20%. in group A versus 66.7% in group B at fully awake and 16% in group A versus 58,8% in group B at 2 hours of post-extubation. However, there was not any significant difference in sore throat incidence of both groups at 4 hours post-extubation (p = 0.394). In conclusion, giving ketamine gargle 40 mg 5 minutes before intubation is more efficient in reducing sore throat after endotracheal tu be-general anesthesia compared with benzydamine HCI 0.075% at fully awake and 2 hours post-extubation.

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Detail Information

Series Title

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Call Number

Journal of the Medical Sciences, 44 (2) 2012 : 181

Publisher

Yogyakarta : FK Universitas Gajah Mada Yogyakarta., 2012

Collation

9p

Language

ISBN/ISSN

0126-1312

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

ketamine
BENZYDAMINE
PHARYNGITIS

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