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Efek Hipoglikemik Kombinasi Infus Daun Talok dengan Metformin dan Glibenklamid pada Tikus Diabetes yang Diinduksi Na2EDTA (Hypoglycemic Effect of Talok Leaves Infuse in Combination with Metformin and Glibenclamide on Na2EDTA Induced-Diabetic Rats)

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Talok (Muntingia calabura L.) leaf is a traditional medicinal plant which empirically used to treat diabetes mellitus. This research aimed to know hypoglycemic effect of combination dose of talak leaves infuse-metformin and glibenclamide on Na2EDTA induced-diabetic rats. Diabetic animal model were conducted by induction of Na2EDTA dose of 70 mg/kg bw for 3 days. The test groups divided into six groups which were treated with: 50 mg/kg bw CMC-Na suspension (negative control/1st group), 0.9 mg/kg bw glibenclamide (2nd group), metformin 90 mg/kg bb (3rd group), 900 mg/kg bw talok leaves infuse (4th group), combination of talak leaves infuse-glibenclamide (450 mg : 0.45 mg/kg bw) 5th group), combination of talok leaves infuse-metformin (450 mg : 45 mg/kg bw) (6th group). The [evels of blood glucose were examined in all 6 experimental groups on day 0, 4th and 7th. The data obtained were analyzed by one way ANOVA (p < 0.05). The results showed that all of combination could decrease the blood glucose levels significantly. The combination treatment of talok leaves infuse-glibenclamide showed a higher hypoglycemic effect than either drug alone, while combination treatment of talak leaves infuse-metformin showed asimilar hypoglycemic effect to either drug alone.
Keywords: Muntingia calabura leaves, metformin, glibenclamide, Na2EDTA, antidiabetic.

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Judul Seri

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No. Panggil

Jurnal Ilmu Kefarmasian Indonesia, 10 (2) 2012 : 9

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Jakarta : Jurnal Ilmu Kefarmasian Indonesia FF Universitas Pancasila., 2012

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6p

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1693-1831

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