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Free Radical Scavenging Activity and Antihyperglycemic Potency of Various Gambier Collected from Several Indonesian Markets (Akivitas Penangkapan Radikal Bebas dan Potensi Antihiperglikemik Beberapa Gambir dari Beberapa Pasar Indonesia)

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Gambier (Uncaria gambier) is known to have antioxidant properties and some studies attributed to the presence of polyphenols. The objective of this study was to investigate the potential of various gambier available in Indonesian market as free radical scavenger and to evaluate its antihyperglycemic potency as α-glucosidase inhibitor. Isolation of catechin was carried out by extraction with distilled ethyl acetate as solvent. Analysis of catechin in the gambier dried extracts were carried out by TLC method. The molecular weight and catechin content of gambier dried extracts were determined by analyzing mass spectra and spectrophotometry, respectively. The free radical scavenging activity of extracts were measured by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) as stable free radical compound. The antihyperglycemic potency of gambier dried extracts were assayed, as α-glucosidase inhibitor.
The results showed that various gambier available in the market were very active as antioxidant, indicated by the ICso values of gambier dried extracts were 4.6 to 18.2 µg/rnl, . Whilst the ICso for a-glucosidase inhibition varies from 40.45 to 52.43 µg/rnl., and classified as a moderate antidiabetic.
Keywords: Uncaria gambier, antioxidant, antihyperglycemic, extract, α-glucosidase.

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Ketersediaan

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Judul Seri

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No. Panggil

Jurnal Ilmu Kefarmasian Indonesia, 10 (2) 2012 : 8

Penerbit

Jakarta : Jurnal Ilmu Kefarmasian Indonesia FF Universitas Pancasila., 2012

Deskripsi Fisik

6p

Bahasa

ISBN/ISSN

1693-1831

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Tipe Media

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