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Penurunan Nilai Ambang Dengar Penderita Keganasan Kepala Leher yang Mendapat Kemoterapi Cisplatin dan Radiasi Eksternal (The Decrease of Bone Conduction Threshold of Head and Neck Cancer Patients Treated by Cisplatin and External Radiation)

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Background: Cisplatin and external radiation either singular or combined, produce free radicals that can cause damage to hair cell of organ corti with the decrease of bone conduction threshold on pure tone audiogram. The aim is to prove that the decrease of bone conduction threshold pure tone audiogram in the group of head and neck cancer patients who received cisplatin and external radiation is greater than the group with cisplatin only.
Methods : A randomized controlled trial pre-post test group design reseach. Subjects that met the inclution criteria at ENT-H&N clinic and ward of Kariadi Hospital, Semarang divided into two groups; cisplatin + 2000 cGy external radiation (studied group) and cisplatin only (control group). The data include the bone conduction threshold pure tone audiometry of two original groups. The data were analized with Chi-square test and Independent-sample ttest.
Results : Twenty-nine subjects were divided into 2 groups; 14 subjects of the study group and 15 subjects of control group. The average of bone conduction threshold of the study group and the control group was not significantly different, (right ear p=0.34; left ear p=0.26). The decrease of bone conduction threshold in the study group is higherthan that of the control group with significant differences in the bone conduction threshold (right ear p=0.02; left ear p=0.001).
Conclusion: The decrease of bone conduction threshold pure tone audiogram in head and neck cancer patients who received cisplatin and external radiation therapy proved greater than that of the group with cisplatin only.
Keywords: Head and neck cancer, cisplatin and external radiation, bone conduction

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Medica Hospitalia: Journal of Clinical Medicine,

Penerbit

Semarang : Medica Hospitalia-Dr. Kariadi Hospital., 2012

Deskripsi Fisik

6p

Bahasa

ISBN/ISSN

2301-4369

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

CISSPLATIN

Info Detail Spesifik

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Pernyataan Tanggungjawab

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