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Efek Eicosapentaenoic Acid Terhadap CD8+dalam Darah Pasien Kanker Payudara Stadium III B yang Mendapat Kemoterapi Cyclophosphamide Adriamycin Fluorouracyl Siklus Pertama (The effect of eicosapentaenoic acid on COB + number of breast cancer stadium 1118 patients receiving first cycle CAP)

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Background: Eicosapenaenoic acid (EPA) has immune-modulating effects and may improve nutritional status in cancer especially in relation to its role in tumour cachexia. The aim ofthe study was to evaluate the efficacy of administration eicosapentaenoic acid for increasing the CD8+ of the stadium IIIB invasive ductus breast cancer patients underwent the first cycle chemotherapy with Cyclophosphamide Adriamycin Fluorouracyl.
Methods: The experimental study was conducted to women with stadium IIIB invasive ductus breast cancer who underwent chemotherapy with Cyclophosphamide Adriamycin Fluorouracyl (CAF) cycle I. The subjects were divided into 2 groups, the experimental group who got the EPA 225 g/day for 21 days and the control group without the EPA supplementation. The CD8+ cells numberwere measured before and after supplementation.
Results: Forty patients treated on the first cycle of CAF chemotherapy decided into 2 groups equaly. Twenty people on the experimental group and 20 on the control group. The number of CD8+ on the experimental group was significantly increased 1131,7 cells/µl (483-3506) compared the control group 631,8 cells/µl (227-1616) (p< 0,05). After 21 days, significant differences between CD8+ cells number were observed before and after supplementation on both group (p

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Ketersediaan

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Judul Seri

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No. Panggil

Media Hospitallia, 1 (1) 2012 : 47-52

Penerbit

Semarang : Puslitbang Farmasi, Badan Litbang Kesehatan., 2012

Deskripsi Fisik

6p

Bahasa

ISBN/ISSN

2301-4369

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Tipe Media

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