2 type of blood transfusion. Complete clinical response revealed at 26 patients (43.3%). There were no association between anemia before or during chemoradiation and complete clinical response (OR 2.38 ; 95% CI 0.71-8.15; p=0.116) and (OR 2.63; 95% CI 0.63-11.66; p=0.136) respectively. Conclusion : Blood transfusion improved the negative impact of hematological toxicity during chemoradiation. There was no association between anemia and complete clinical response. Keywords : carcinoma of cervix, hematology toxicity, blood " />
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Hubungan Anemia dan Transfusi Darah terhadap Respons Kemoradiasi pada Karsinoma Serviks Uteri Stadium IIb - IIIlb (The association of anemia and blood transfusion to the chemoradiation response of stage IIb-IIIb cervical cancer

Background: Cervical carcinoma is the second most common women cancer in the world. Radiation and chemotherapy are the main cervical carcinoma treatment. They kill the cancer cells, but have some effects to the hematological problem. The objective of the study is to evaluate the effects of anemia and hematology toxicity to the response of complete chemoradiation in stage IIB-IIIB cervical cancer.
Methods : A prospective cohort study was conducted at Obstetry and Gynecology ward Dr. Kariadi Hospital from August 2010-January 2011. The inclusion criteria was IIB-"IB stage cervical patients received chemoradiation. Laboratorium examination was done after completing 5 external radiation and before brachytherapy. Clinical respons was evaluated 3 months after chemoradiation.
Results: During 6 months 60 patients enrolled to the study, 74.19% revealed squamous cell carcinoma, 75.81% on "IB stage. Out of 60 patients, 45.97% had anemia, 32.27% leucopenia and 13.7% got thrombocytopenia. Fifty two patients (86.7%) received blood transfusion, 44 patients of them (73.33%) had one and 8 (26.67%) had > 2 type of blood transfusion. Complete clinical response revealed at 26 patients (43.3%). There were no association between anemia before or during chemoradiation and complete clinical response (OR 2.38 ; 95% CI 0.71-8.15; p=0.116) and (OR 2.63; 95% CI 0.63-11.66; p=0.136) respectively.
Conclusion : Blood transfusion improved the negative impact of hematological toxicity during chemoradiation. There was no association between anemia and complete clinical response.
Keywords : carcinoma of cervix, hematology toxicity, blood

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Location name is not set Media Hospitallia, 1 (1) 2012 : 32-36
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Media Hospitallia, 1 (1) 2012 : 32-36
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: Medica Hospitalia-Dr. Kariadi Hospital.,
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5p
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2301-4369
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