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Pengaruh Pemberian Ketamin Dosis 0,1, 0,2 dan 0,4 mg/kgBB terha.dap Kadar Nitric Oxide Makrofag Mencit Balb/c yang Diberi Lipopolisakarida (The effect of ketamine 0.1, 0.2 and 0.4 mg/kg doses on the nitric oxide level of Balb/c mice macrofag folIowing Lipopolysaccharide injection)

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Background: Nitric oxide (NO) has a potential rule in pathogenesis of systemic hypotension in septic shock. Endotoxin has been shown to increase the activity of the iNOS enzyme and NO release. Proinflamatory cytokines are inflammatory mediators which implicated in the induction and anion of iNaS and NO release also. Ketamine is anesthetic agent and commonly used for patients. This agent suppressed endotoxin induced proinflamatory cytokines production and blockade the activation of NF-kB, 50 the NO production can be inhibited. Objective of the study was to know the effect of Ketamine 0,1; 0,2 and 0,4 mg/kg intravenous on intraperitoneal NO level of Balb/c mice injected with lipopolysaccharide intraperitoneally.
Methods : a randomized post test only control/ed group laboratoric experimental study on animal,20 male Balb/c mice divided into 4 groups, PI as the control group. All mice were injected popolysaccharide 20mg/kg intraperitoneally and 6 hours later were injected by ketamine 0,1; 0,2; and 0,4 mg/kg intravenously in group P2, P3, and P4 respectively. NO was taken from peritomeal macrophage culture and observed by Grease method. The data were analyzed by ANOVA and post hoc statistical assay, with reliability p

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Judul Seri

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No. Panggil

Media Hospitallia, 1 (1) 2012 : 12-15

Penerbit

Semarang : Medica Hospitalia-Dr. Kariadi Hospital., 2012

Deskripsi Fisik

4p

Bahasa

ISBN/ISSN

2301-4369

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Tipe Media

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Tipe Pembawa

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