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Epilepsy surgery in lndonesia:Achieving better result with limited resources

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Background: Even with modern medication, 30 to 40% of epilepsy patients will be intractable and th is condition leads to cognitive and psychosocial decline, resulting in worse quality of life and higher mortality. With 0.5-0.6% prevalence, there will be about 1.5 million epileptic in lndonesia, about 440.000 will be intractable, and 220.000 of th em are potential candidates for epilepsy surgery (ES). A decade has passed since the first ES performed on July 1999, and the number increases every year reaching 35-47 ES per year in 2007-2009. Despite the excellent result shown, all of these ES were still performed in Semarang (Diponegoro University) while the patients were from all part of lndonesia. The major reason behind the unavailability of ES in most part of the country should be discussed for the sake offuture development of ES in lndonesia.
Material: Epilepsy surgery was started in July 1999 with anterior temporal lobectomy for a 34 Y-old female with left mesial temporal scIerosis (MTS) causing a long standing intractable seizures. The number of cases increases every year. Until the end of 2009, there were 238 cases of epilepsy surgery, including 212 anterior temporallobectomies. Among these, 106 cases had been follow up more than 36 months, and evaluated for surgical results.
Methods: To evaluate the patient's selection and the presurgical evaluation, we divide the ES cases into the first 5 years (56 cases) and the recent 5 years (182 cases). But for the purpose of evaluating surgical results, only those with at least 36 months postoperative follow-up were included (106 cases) and grouped into those operated before or after the age of 25 Y-old {group A and group BJ, and into those operated before or afterthe length of epilepsy of 10 years (group I and group II).
Results: For the first five years-period, decision to operate were based on MRI and routine interictal EEG in 54 out of 56 TLE cases. One patient had long-term ictal EEG and another had subdural grid EEG implanted, since MRI in both patients showed visually normal MR!. For the lastfive years, decision to operate were based on MRI and routine EEG in 91 out of 156 TLE cases. Longterm ictal EEG were performed in 46 patients, subdural grid EEG in 10 patients, PET study in 7 patients, and EcoG in 2 patients. The overall seizure free (SF) rate were 70.75%, but if grouped according to patient's age at surgery {less than or over 25 v-old}, the SF rates were 75.4% vs 66.04% respectively. 50 did if grouped according to length of disease {less than or more than 10 vears), the SF rates were 78.72% vs 64.40% respectively.
Conclusion: MRI plays very important role to decide the side of the epileptictemporal side, but this role is decreasing as it was 96.4% during the beginning five years to become 58.34% for the last five years. This means that we are working on more difficult epilepsy cases recently. SF rate was significantly higher for those who was operated at younger age and for those with shorter duration of epilepsy. This means that surgery should be offered earlier for those intractable TLE patients with obvious focus on MR!.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Media Hospitallia, 1 (1) 2012 : 1-6

Penerbit

Semarang : Medica Hospitalia-Dr. Kariadi Hospital., 2012

Deskripsi Fisik

6p

Bahasa

ISBN/ISSN

2301-4369

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Tipe Media

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Tipe Pembawa

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