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Optimasi Perbandingan Hidroksi Propil Metil Celulosa Dengan Eudragit Rs 30 D Sebagai Penyalut Terhadap Profil Disolusi Mikrokapsul Diltiazem Hidroklorida Metode Pengeringan Semprot (Optimization of Gomparison of Hydroxy Propyl Methyl Celluse with Eudragit RS 30 D as the Goating Agent to the Profile Dissolution of diltiazem hydrochloride microcapsules with a spray drying method)

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Diltiazem HCI is used as an antihypertensiON and has a very short half-Iife, making ii suitable if made in the form of microcapsules. Research using HPMC and Eudragit RS 30 D as coating end aimed at finding the best ratio of diltiazem HCI microcapsules prepared by spray drying method, in terms of the dissoluiion profile. The microcapsules are made in a homogeneous solution of the active substance and the coating is then atomized by means of spray drying at a temperature determined by the carrier substance. Evaluation on the microcapsules were the SEM (Scanning Electron Microscop), particle size distribution, the recovery factor is accompanied by adsorption and dissolution testing on two conditions to determine the release of active substances in absorb ed microcapsules. Data obtained from the results were from the dissolution of the coating. Analysis of the data used isANOVA one direction (p

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Detail Information

Series Title

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Call Number

FARMASAINS : Jurnal Ilmiah Ilmu-ilmu Kefarmasian,

Publisher

Jakarta : Jurusan Farmasi Uhamka Jakarta., 2012

Collation

6p

Language

ISBN/ISSN

2086-6968

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

CAPSULES
DILTIAZEM

Specific Detail Info

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Statement of Responsibility

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