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The relationship between vitamin A and ferritin towards malondialdehyde level among Javanese male smokers

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Cigarette smokes produce a large number of oxidants and promote secretion of ferritin by alveolar macrophages which are potential to encourage the lipid peroxidation. Malondialdehyde (MDA) is used as a parameter of lipid peroxidation. The study was aimed to evaluate the relationship between blood level of vitamin A and ferritin and MDA among Javanese male smokers. Sixty men who lived in Purworejo District, Central Java, lndonesia comprising 30 smokers as case group and 30 nonsmokers as control group were involved in th is study. Blood sampie was obtained from cubiti vein and then centrifuged to obtain plasma or serum. Blood levels of vitamin A, ferritin and MDA were measured by HPLC, ELlSA and spectrophotometric methods, respectively.
The result showed that the blood vitamin A, ferritin, and MDA levels in smokers were 25.09 ± 9.51µg/dL, 35.50 ± 24.17ng/dL, 1.15 ± 0.42µg/L, respectively, whereas in non smokers, they were 26.11 ± 9.19 µg/dL, 38.60 ± 15.25 ng/dL, 1.06 ± 0.50 µg/L, respectively. There was no significant difference of the blood vitamin A, ferritin, and MDA levels between smokers and the non smokers (p > 0.05). The linear regression analysis indicated that there was negative relationship between blood vitamin A and MDA levels although it was not significant (p = 0.052). while blood ferritin and MDA levels had a significantly positive relationship (p = 0.01 0).
In conciusion, the low level of blood vitamin A among cigarette smokers does not lead to high blood MDA level, while high level of blood ferritin among smokers leads to high blood MDA level.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Journal of The Medical Sciences, 44 (1) 2012 : 92-

Penerbit

Yogyakarta : FK Universitas Gajah Mada Yogyakarta., 2012

Deskripsi Fisik

7p

Bahasa

ISBN/ISSN

0126-1312

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

vitamin a
smoke
ferritin
malondialdehyde

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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