The relationship between vitamin A and ferritin towards malondialdehyde level among Javanese male smokers | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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The relationship between vitamin A and ferritin towards malondialdehyde level among Javanese male smokers

Ajeng Viska Icanervilia - Personal Name; Ahmad Hamim Sadewa - Personal Name; Sunarti; - Personal Name;

Cigarette smokes produce a large number of oxidants and promote secretion of ferritin by alveolar macrophages which are potential to encourage the lipid peroxidation. Malondialdehyde (MDA) is used as a parameter of lipid peroxidation. The study was aimed to evaluate the relationship between blood level of vitamin A and ferritin and MDA among Javanese male smokers. Sixty men who lived in Purworejo District, Central Java, lndonesia comprising 30 smokers as case group and 30 nonsmokers as control group were involved in th is study. Blood sampie was obtained from cubiti vein and then centrifuged to obtain plasma or serum. Blood levels of vitamin A, ferritin and MDA were measured by HPLC, ELlSA and spectrophotometric methods, respectively.
The result showed that the blood vitamin A, ferritin, and MDA levels in smokers were 25.09 ± 9.51µg/dL, 35.50 ± 24.17ng/dL, 1.15 ± 0.42µg/L, respectively, whereas in non smokers, they were 26.11 ± 9.19 µg/dL, 38.60 ± 15.25 ng/dL, 1.06 ± 0.50 µg/L, respectively. There was no significant difference of the blood vitamin A, ferritin, and MDA levels between smokers and the non smokers (p > 0.05). The linear regression analysis indicated that there was negative relationship between blood vitamin A and MDA levels although it was not significant (p = 0.052). while blood ferritin and MDA levels had a significantly positive relationship (p = 0.01 0).
In conciusion, the low level of blood vitamin A among cigarette smokers does not lead to high blood MDA level, while high level of blood ferritin among smokers leads to high blood MDA level.

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Location name is not set Journal of The Medical Sciences, 44 (1) 2012 : 92-

A0003284

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Detail Information

Series Title: -
Call Number: Journal of The Medical Sciences, 44 (1) 2012 : 92-
Publisher: Yogyakarta : FK Universitas Gajah Mada Yogyakarta., 2012
Collation: 7p
Language
ISBN/ISSN: 0126-1312
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): vitamin a
smoke
ferritin
malondialdehyde
Specific Detail Info: -
Statement of Responsibility: -

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