Correlation between overt hyperthyroid and subclinical hyperthyroid and cognitive impairment in Dr. Sardjito General Hospital, Yogyakarta, lndonesia | Perpustakaan dan Galeri Kebijakan Kesehatan

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Correlation between overt hyperthyroid and subclinical hyperthyroid and cognitive impairment in Dr. Sardjito General Hospital, Yogyakarta, lndonesia

Berkat Hia - Nama Orang; Pernodjo Dahlan - Nama Orang; Abdul Ghofir - Nama Orang;

Hyperthyroidism is a metabolic imbalance resulting from excessive production of thyroid hormones. Overt or subclinical hyperthyroid prevalence has reached 20%. The differences in thyroid status induce apoptosis in adult cerebral cortex. Triiodothyroxine (T3) acts directly on the cerebral cortex mitochondria and induces the release of cytochrome-c which leads to apoptosis. The increase of hormone levels encountered in hyperthyroidism which is associated with an increase in necrotic death of neurons and oxidative stress has a negative effect on cognition. Several studies demonstrated the significant association of hyperthyroidism with cognitive impairment, despite remaining as controversial results. The study aimed to evaluate the correlation between overt hyperthyroid and subclinical hyperthyroid and cognitive impairment in hyperthyroidism patients. This was a cross-sectional study involving 68 patients of hyperthyroidism who were treated in Endocrine Clinic of Dr. Sardjito General Hospital, Yogyakarta. The inclusion criteria were hyperthyroidism based on anamnesis, clinical examination and laboratory tests, age of 20- 60 years, symptoms of hyperthyroidism, and minimum education of elementary school. The relationship of hyperthyroidism and cognitive impairment, and multivariate analysis was analyzed by Chi-square and logistic regression tests, respectively. The results were considered as statistically significant if the value of p was

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Belum memasukkan lokasi Journal of The Medical Sciences, 44 (1) 2012 : 57-

A0003278

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Informasi Detail

Judul Seri: -
No. Panggil: Journal of The Medical Sciences, 44 (1) 2012 : 57-
Penerbit: Yogyakarta : Puslitbang Farmasi, Badan Litbang Kesehatan., 2012
Deskripsi Fisik: 8p
Bahasa
ISBN/ISSN: 0126-1312
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: HYPERTHYROIDISM
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

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