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The droplet size changes of 1% propofol before and after the storage procedure for 6 and 24 hours periods
Propofol (2,6-diisopropylphenol) is a popular anesthetic agent for induction and anesthetic maintenance. Propofol preparation is formulated as a lipid macroemulsion that is thermodynamically unstable and degraded over time, causing the enlargement of droplet size. The degradation is faster when propofol emulsion preparation package has been opened. This droplet enlargement results in decreasing propofol releasing-rate and its concentration. The risk of embolism occurs whenever the mean droplet size (MDS) exceeds Food and Drug Administration (FDA) limit (5 µm (PFAT5) is
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