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Sifilis Laten: Diagnosis Dan Pengobatan
Latent syphilis is one of the syphilis stadiums caused by T. pallidum which is asymptomatic however it shows reactive serology. Patient with latent syphilis without treatment will have the disease throuqnout their whole life and will increase the risk for HIV infection. Pregnant women with latent syphilis will transmit the disease to 40% of the babies, 20% will be premature, 10% will be still bom and 4% will die during delivery.
The diagnosis of early latent syphilis is established when in the last 12 months one or more of the followinq signs are found : four times or more increased titers of VDRL or RPR; history of symptoms of primary and secondary syphilis; ahistory of sexual contact with someone who was diagnosed with syphilis or suspected of having primary, secondary syphilis or early latent syphilis; history of sexual contact with someone who has VDRL or RPR and TPHA reactive tests. The recommended treatment for early sypililis is a single dase of 2.4 million lU benzathine penicillin, 1M, whereas for late syphilis, three dosis of 2.4 million lU benzathine penicillin, 1M administered with the intervals of one week. Examination of non-treponemal syphilis serology tests (VDRL or RPR) should be performed at three months, six months, 12 and 24 months after treatment, to assess the treatment outcome.
Key words: Latent syphilis, Diagnosa, Therapy
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