Prognostic factors of neuroinflammation and oxidative stress in brain injury patients at Cipto Mangunkusumo Hospital Jakarta | Perpustakaan dan Galeri Kebijakan Kesehatan

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Prognostic factors of neuroinflammation and oxidative stress in brain injury patients at Cipto Mangunkusumo Hospital Jakarta

Renindra A. Aman - Nama Orang; Nia Yuliatri - Nama Orang; Mohammad A. Aulia - Nama Orang; Syaiful Ichwan - Nama Orang; Alida Harahap - Nama Orang; Yusuf Wibisono - Nama Orang; Hans-Joachim Freisleben - Nama Orang;

Results: The post-operative IL-6 serum level showed a downward trend compared to pre-operative value (mean decrease: -190.61 pg/mL). The post-operative IL-6 level was significantly associated with GCS 7 days post-operation (p = 0.006), with OR 24. The post-operative IL-6 serum level was significantly associated with GOS 3 months post-trauma (p = 0.016) with OR 11.6. The post-operative uric acid serum level showed a downward trend compared to pre-operative value (mean decrease: -0.26 mg/dL). There was a significant difference between the mean value ofpost-operative uric acid serum level in patients with 7 days post-trauma with GCS < 8 (mean: 4.16 mg/dL) and GCS > 8 (mean: 2.71 mg/dl.), (p = 0.042). The post-operative MDA serum level showed a down ward trend compared to pre-operative value (mean decrease: -0.08 nmol/mL). There is no significant association between MDA serum level, GCS and GOS and no significant association of NR2A antibody and GSH serum level with GCS, GOS and neurosurgical procedure. From the multivariate analysis, the most important neuroinfiammatory variable associated with GCS and GOS is IL-6.
Conclusion: Neuroinflammation and oxidative stress may have prognostic values in brain-injured patients, in particular IL-6. Neurosurgical procedures may decrease the neuroinflammation process.
Keywords: Neuroinflammation, oxidative stress, traumatic brain injury, neurosurgical procedures, interleukin 6, uric acid, malondialdehyde, NR2A antibody, glutathione

Ketersediaan

Belum memasukkan lokasi Medical Journal Indonesia, 21 (3) 2012 : 152-159

A0003244

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Judul Seri: -
No. Panggil: Medical Journal Indonesia, 21 (3) 2012 : 152-159
Penerbit: Jakarta : FK universitas indonesia., 2012
Deskripsi Fisik: 8p
Bahasa
ISBN/ISSN: 2252-8083
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: brain injuries
OXIDATIVE STRESS
NEUOGENIC INFLAMMATION
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

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