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Peran Vitamin D Terhadap Kerusakan Jaringan Paru Pada Mencit Yang Terinfeksi Mycobacterium tuberculosis

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Eradication effort of tuberanosts disease in Indonesia has been carried out by implementing the strategy of Directly Observed Treatment Short-Coarse (DOTS) free of charge. However; its prevention and eradication are still unsatisfactory. Vitamin D expected to be able to enhance intracellular immune response. However, the mechanism is still unclear. An experimental research using randomized post-test control group design was selected in this study. Twenty four mice were selected and allocated randomly into two groups. Twelve mice in one group were given 100ng of vitamin D orelty, while twelve mice in another group were not given vitamin D. Then each group was allocated randomly into two sub groups of six mice. Six mice in one sub group were infected with Mycobacterium tuberculosis. while six mice in another sub group were not infected with Mycobacterium tuberculosis. The results It implies that vitamin D may detain lung tissue demage due to tuberculosis. The mechanism of the role of vitamin D on immunity against Mycobacterium tuberculosis through increasing IFN-y conceatretton, minimizing granuloma process.
Keywords: Vitamin D, Mycobacterium tuberculosis/ granuloma.

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Series Title

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Call Number

Jurnal Penelitian Kesehatan, 10 (2) 2012 : 95-102

Publisher

Surabaya : Poltekes Surabaya., 2012

Collation

7p

Language

ISBN/ISSN

2087-1163

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Carrier Type

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Edition

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Subject(s)

lung
VITAMIN D
MYCOBACTERIUM TUBERCULOCIS

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