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Efek Hipoglikemik Kombinasi Infus Daun Talok dengan Metformin dan Glibenklamid pada Tikus Diabetes yang Diinduksi Na2EDTA(Hypoglycemic Effect of Talok Leaves Infuse in Combination with Metformin and Glibenclamide on Na2EDTA Induced-Diabetic Rats

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Talak (Muntingia calabura L.) leaf is a traditional medicinal plant which empirically used to treat diabetes mellitus. This research aimed to know hypoglycemic effect of combination dose of talak leaves infuse-metformin and glibenclamide on Na2EDTA induced-diabetic rats. Diabetic anirnal model were conducted by induction of Na2EDTA do se of 70 mg/kg bw for 3 days. The test groups divided into six groups which were treated with: 50 mg/kg bw CMC-Na suspension (negative control 1/1st group), 0.9 mg/kg bw glibenclamide (2nd group), metformin 90 mg/kg bb (3rd group), 900 mg/kg bw talak leaves infuse (4th group), combination of talak leaves infuse-glibenclamide (450 mg : 0.45 mg/kg bw) (5th group), combination of talak leaves infuse-metformin (450 mg: 45 mg/kg bw) (6th group). The levels of blood glucose were examined in all 6 experimental groups on day 0, 4th and 7th. The data astained were analyzed by one way ANOVA (p < 0.05).
The results showed that all of combination could decrease the blood glucose levels significantly. The combination treatment of talok leaves infuse-glibenclamide showed a higher hypoglycemic effect than either drug alone, while combination treatment of talok leaves infuse-metformin showed a similar hypoglycemic effect to either drug alone.
Keywords: Muntingia calabura leaves, metformin, glibenclamide, Na2EDTA, antidiabetic

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Jurnal Ilmu Kefarmasian Indonesia, 10(2) 2012 : 93

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Jakarta : FF Universitas Pancasila., 2012

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6p

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1693-1831

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