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Metabolisme Energi Pada Cedera Otak Traumatik (Energy Metabolism In Traumatic Brain Injury)
During Traumatic brain injury, secondary insults will led to physiological and biochemical cascade that disturbing cerebral energy metabolism. After traumatic brain injury, sustained changes in cellular energy metabolism have been described as accelerated glycolysis or mitochondrial dysfunction. Traumatic brain injury is associated with increasing energy needs to res tore cerebral ionic hemostasis, distubance in glutaminergic process and tissue repairing.
Combination of ATP release from pre-terminal synaps, mitochondrial dysfunction, decrease brain oxygen delivery and increasing energy metabolic needs results in cerebral energy imbalances.
Key words: Traumatic brain injury, cerebral energy metabolism
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