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Free Radical Scavenging Activity and Antihyperglycemic Potency of Various Gambier Extracted from Several Indonesian Markets (Aktivitas Penangkapan Radikal Bebas dan Potensi Anthiperglikemik Beberapa Gambir dari Beberapa Pasar Indonesia)

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Gambier (Uncaria gambier) is known to have antioxidant properties and some studies attributed to the presence of polyphenols. The obyective of this study was to investigate the potential of various gambier availabel in Indonesian market as free radical scavenger and to evaluate its antihyperglycemic potency as α -glucosidase inhibitor. Isolation of cathechin was carried out by extration with distilled ethyl acetate as solvent. Analysis of catechin in the gambier dried extracts were carried out by TLC method. The molecular weight and catechin conten of gambier dried extract were determinedby analyzing mass spectra and spectrophotometry, respectively. The free radicalscavenging activity of extracts were measured by using 1,1-diphenyl-2picrylhydrazyl (DPPH) as stable free radical compound. The antihyperglycemic potency of gambier dried extracts were assayed, as α-glucosidase inhibitor. The results showed that various gambier available in the market were very active as antioxidant, indicated by the IC50 values of gambier dried extracts were 4.6 to 18.2 ug/mL. Whilst the IC50 for α-glucosidase inhibition varies from 40.45 to 52.43 ug/mL, and classified as a moderate antidiabetic.
Keyword : Uncaria gambier, antioxidant, antihyperglycemic, extract, α-glucosidase

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Judul Seri

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No. Panggil

Jurnal Ilmu Kefarmasian Indonesia 10 (2) 2012 : 81

Penerbit

Jakarta : FF Universitas Pancasila., 2012

Deskripsi Fisik

6p

Bahasa

ISBN/ISSN

1693-1831

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