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Epigallocatechin Gallate Menghambat Resistensi Insulin pada Tikus dengan Diet Tinggi ternak (Inhibitory Effect of Epigallocatechin Gallate on Insulin Resistance in Rat with High Fat Diet

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Consumption of epigallocatechin gallate (EGCG) of green tea were reported to have much benefit in improving health, such as increased fat oxidation, prevent obesity and improve insulin sensitivity. EGCG of green tea (Cam elia sinensis) from GMB4 done may serve as a potential therapeutic agent for obesity and insulin resistance. Th is study investigated the effect isolat Epigallocatechin Gallate (EGCG) from green tea inhibit increasing adipose tissue sterol regulatory element-binding protein 1( SREBP-1) and insulin resistance in male rats with high fat diet. Wistar male rats werefed a diet high in jat jor 2 months from 6-8 weeks of age and determination of the object of research with completely randomized design with five treatments, namely (1) rats with standard feed diet (2) rats with a diet high in fat, (3) rats with high-fat diet + EGCG lmg/kgBW, (4) rats with high-fat diet + EGCG 2 mg/kgBW, (5) rats with high-fat diet + EGCG 8 mg/kgBW Feeding rats administered orally, whereas EGCG per sonde lx/day. Plasma Insulin and adipose tissue SREBP-1 was measured by ELlSA and blood glucose by spektrophotometry. EGCG treatment decreased viscerai fat, blood qlucose, insulin, and HaMA-IR (p

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Jurnal Kedokteran Brawijaya, 27 (1) 2012 : 43-50

Publisher

Malang : FK Universitas Brawijaya., 2012

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8p

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0216-9347

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